Question 17.
All of the following except one are characteristic features of granulomatosis with polyangiitis (Wegner's granulomatosis). Which is the exception? (AIIMS)
1. Nodular pulmonary lesion
2. Intractable rhinitis and sinusitis
3. Terminal uremia
4. Congestive cardiac failure
DISCUSSION:
A triad of upper respiratory tract disease (including rhinitis, sinusitis, and otitis media), lower respiratory disease (including pulmonary nodules and cavities), and glomerulonephritis characterizes granulomatosis with polyangiitis (Wegner's granulomatosis). Renal disease is the major cause of mortality in this disease. The heart, gastrointestinal tract, and central nervous system are infrequently affected in this disorder. Congestive cardiac failure is not a typical feature of Wegner’s granulomatosis.
ANSWER:
The correct answer is “congestive heart failure.”
REFERENCE:
Seo P, Stone JH (July 2004). The antineutrophil cytoplasmic antibody-associated vasculitides. Am. J. Med. 117 (1): 39–50.
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